Invited Lectures Prof. Jean-Jacques Toulmé (Inserm, France) Sponsored by the Chemical Biology Group (GEQB-RSEQ) of the Royal Society of Chemistry of Spain (RSEQ) Structure-switching aptamers: detecting targets with a kiss Prof. Philipp Holliger (Medical Research Council Laboratory of Molecular Biology, Cambridge, UK) Synthetic genetics: beyond DNA and RNA Prof. Chris Meier (Universität Hamburg, Germany) Developing Prodrugs of antivirally active Nucleoside Triphosphates - Against all odds, it works! Download the programme HERE Download the Book of Abstacts HERE Monday 3rd July 9:00 – 9:35
Registration Structure-switching aptamers: detecting targets with a kiss 10:25 – 10:45 Miguel Moreno (CSIC-INTA) Development of quantitative PCR-based technologies for the functional characterization of RNA and DNA aptamers 10:45 – 11:05 Francisco Javier Cao García (UCM) Mechanics, Thermodynamics and Kinetics of ligand binding to biopolymers 11:05 – 11:40 Coffee Break 1 & Poster Session
Session II (Chair: Carlos González) 11:40 – 12:00 Marian Oliva Blanco (CIB-CSIC) Two functions in one nucleoprotein complex: transcriptional regulation and DNA segregation during TubR-tubC assembly in virulent plasmids 12:00 – 12:20 David González Rodríguez (UAM) Toward a radical change in DNA assembly: Tubular Quadruplex DNA 12:20 – 12:40 Pablo Peñalver Puente (López Neyra) Carbohydrate-DNA interactions: glucose-nucleobase pairs studied using model systems 12:40-13:00 José Gallego Sala (UCV) The 3’X terminal RNA tail of hepatitis C virus studied by NMR spectroscopy and SAXS
13:00-14:25 Lunch at the cafeteria
14:30-15:15 Invited Lecture 2 (Prof. Philipp Holliger) Synthetic genetics: beyond DNA and RNA 15:15-15:35 Borja Ibarra DNA synthesis determines the binding mode of the human mitochondrial single-stranded DNA-binding protein 15:35-15:55 Ana Bravo García (UAH) Multi-domain conformational variations in LiEndoG result in significant changes in the regulation of its nuclease activity
15:55 – 16:30
Coffee Break 2
Session IV (Chair: Federico Gago) 16:30-16:50 Irene Gutiérrez Pérez (IMDEA Nanociencia) The folding complexity of TERRA molecules unveiled at the single-molecule level 16:50-17:20 Bartomeu Mir Morro (Universitat de Barcelona) Monomeric i-motif structures containing minor groove tetrads are formed at neutral pH. 17:20-17:40 Juan Carlos Morales Sánchez (López Neyra) A sweet approach to a new target for cancer therapy: DNA G-quadruplexes 17:40-18:00 Álex Jiménez Félix (University of Barcelona) Immunotherapy using Polypurine reverse
Hoogsteen hairpins to promote breast and prostate cancer cells death by
PMA-differentiated THP-1 cells 10:00-10:45 Invited Lecture 3 (Prof.
Chris Meier) 10:45-11:05 Virginie Lhiaubet (UPV-CSIC) DNA damage and repair at pyrimidine sites 11:05-11:25 Jordi Agramunt Pi (Universitat de Barcelona) Cyclopentenedione-mediated bioconjugation: oligonucleotide and PNA conjugates 11:25 – 12:00 Coffee Break 3 & Poster Session
12:00-12:20 Santiago Grijalvo Torrijo (IQAC-CSIC) Synthesis of Oligonucleotide Conjugates Forming G-quadruplexes: Insights into Gene Silencing, Cellular Uptake and Antiviral Activity 12:20-12:40 Montserrat Terrazas (IRB) Novel bifunctional RNA nanobinders: A promising tool for combined cancer therapy 12:40-13:00 Carlos González (CSIC-IQFR) Structural studies on I-motifs with chemical modifications 13:00-13:20 Silvia María Hernández Ainsa (Cambridge) Applying DNA nanotechnology to Photoacoustics Bioimaging
13:20-13:30 Closing of the XI RANN 13:30 Farewell lunch at the Hall |