Invited Lectures

Prof. Jean-Jacques Toulmé (Inserm, France) 
Sponsored by the Chemical Biology Group (GEQB-RSEQ) of the Royal Society of Chemistry of Spain (RSEQ)
Structure-switching aptamers: detecting targets with a kiss

Prof. Philipp Holliger (Medical Research Council Laboratory of Molecular Biology, Cambridge, UK)
Synthetic genetics: beyond DNA and RNA

Prof. Chris Meier (Universität Hamburg, Germany)
Developing Prodrugs of antivirally active Nucleoside Triphosphates - Against all odds, it works!

Download the programme HERE
Download the Book of Abstacts HERE

Monday 3rd July

9:00 – 9:35  Registration
9:35 – 9:40  Opening of the XI RANN

Session I (Chair: Juan Carlos Morales)
9:40 – 10:25 Invited Lecture 1 (
Prof. Jean-Jacques Toulmé)

Structure-switching aptamers: detecting targets with a kiss

10:25 – 10:45 Miguel Moreno (CSIC-INTA)

Development of quantitative PCR-based technologies for the functional characterization of RNA and DNA aptamers

10:45 – 11:05 Francisco Javier Cao García (UCM)

Mechanics, Thermodynamics and Kinetics of ligand binding to biopolymers

11:05 – 11:40 Coffee Break 1 & Poster Session

Session II (Chair: Carlos González)

11:40 – 12:00 Marian Oliva Blanco (CIB-CSIC)         

Two functions in one nucleoprotein complex: transcriptional regulation and DNA segregation during TubR-tubC assembly in virulent plasmids

12:00 – 12:20  David González Rodríguez (UAM)

Toward a radical change in DNA assembly: Tubular Quadruplex DNA

12:20 – 12:40 Pablo Peñalver Puente (López Neyra)

Carbohydrate-DNA interactions: glucose-nucleobase pairs studied using model systems

12:40-13:00 José Gallego Sala (UCV)

The 3’X terminal RNA tail of hepatitis C virus studied by NMR spectroscopy and SAXS


13:00-14:25 Lunch at the cafeteria

Session III (Chair: Modesto Orozco)
Session sponsored by ChemGenes

14:30-15:15 Invited Lecture 2 (Prof. Philipp Holliger)

Synthetic genetics: beyond DNA and RNA

15:15-15:35 Borja Ibarra                   

DNA synthesis determines the binding mode of the human mitochondrial single-stranded DNA-binding protein

15:35-15:55 Ana Bravo García (UAH)

Multi-domain conformational variations in LiEndoG result in significant changes in the regulation of its nuclease activity


15:55 – 16:30 Coffee Break 2

Session IV (Chair: Federico Gago)

16:30-16:50 Irene Gutiérrez Pérez (IMDEA Nanociencia)

The folding complexity of TERRA molecules unveiled at the single-molecule level

16:50-17:20 Bartomeu Mir Morro (Universitat de Barcelona)        

Monomeric i-motif structures containing minor groove tetrads are formed at neutral pH.

17:20-17:40 Juan Carlos Morales Sánchez (López Neyra)

A sweet approach to a new target for cancer therapy: DNA G-quadruplexes

17:40-18:00 Álex Jiménez Félix (University of Barcelona)    

Immunotherapy using Polypurine reverse Hoogsteen hairpins to promote breast and prostate cancer cells death by PMA-differentiated THP-1 cells      

18:00-18:30 General discussion and election for the site of XII RANN
20:15 Bus departs from campus to Madrid
21:00 Conference dinner at
Asador Real

Tuesday 4th July

Session V (Chair: Maria José Camarasa)

10:00-10:45 Invited Lecture 3 (Prof. Chris Meier)
Developing Prodrugs of antivirally active Nucleoside Triphosphates - Against all odds, it works!

10:45-11:05 Virginie Lhiaubet (UPV-CSIC)    

DNA damage and repair at pyrimidine sites

11:05-11:25 Jordi Agramunt Pi (Universitat de Barcelona)  

Cyclopentenedione-mediated bioconjugation: oligonucleotide and PNA conjugates

11:25 – 12:00 Coffee Break 3 & Poster Session

Session VI (Chair: Anna Grandas)

12:00-12:20 Santiago Grijalvo Torrijo (IQAC-CSIC)   

Synthesis of Oligonucleotide Conjugates Forming G-quadruplexes: Insights into Gene Silencing, Cellular Uptake and Antiviral Activity

12:20-12:40 Montserrat Terrazas (IRB)

Novel bifunctional RNA nanobinders: A promising tool for combined cancer therapy

12:40-13:00 Carlos González  (CSIC-IQFR)    

Structural studies on I-motifs with chemical modifications

13:00-13:20 Silvia María Hernández Ainsa (Cambridge)      

Applying DNA nanotechnology to Photoacoustics Bioimaging


13:20-13:30 Closing of the XI RANN

13:30 Farewell lunch at the Hall